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People use their hands for intricate tasks like playing musical instruments, employing myriad touch sensations to inform motor control. In contrast, current prosthetic hands lack comprehensive haptic feedback and exhibit rudimentary multitasking functionality. Limited research has explored the potential of upper limb amputees to feel, perceive, and respond to multiple channels of simultaneously activated haptic feedback to concurrently control the individual fingers of dexterous prosthetic hands. This study introduces a novel control architecture for three amputees and nine additional subjects to concurrently control individual fingers of an artificial hand using two channels of context-specific haptic feedback. Artificial neural networks (ANNs) recognize subjects’ electromyogram (EMG) patterns governing the artificial hand controller. ANNs also classify the directions objects slip across tactile sensors on the robotic fingertips, which are encoded via the vibration frequency of wearable vibrotactile actuators. Subjects implement control strategies with each finger simultaneously to prevent or permit slip as desired, achieving a 94.49% ± 8.79% overall success rate. Although no statistically significant difference exists between amputees’ and non-amputees’ success rates, amputees require more time to respond to simultaneous haptic feedback signals, suggesting a higher cognitive load. Nevertheless, amputees can accurately interpret multiple channels of nuanced haptic feedback to concurrently control individual robotic fingers, addressing the challenge of multitasking with dexterous prosthetic hands. 

Artificial Intelligence (AI) is poised to revolutionize numerous aspects of human life, with healthcare among the most critical fields set to benefit from this transformation. Medicine remains one of the most challenging, expensive, and impactful sectors, with challenges such as information retrieval, data organization, diagnostic accuracy, and cost reduction. AI is uniquely suited to address these challenges, ultimately improving the quality of life and reducing healthcare costs for patients worldwide. Despite its potential, the adoption of AI in healthcare has been slower compared to other industries, highlighting the need to understand the specific obstacles hindering its progress. This review identifies the current shortcomings of AI in healthcare and explores its possibilities, realities, and frontiers to provide a roadmap for future advancements. 

Abstract Bio-inspired soft-robots are nowadays found their place in many applications due to its flexibility, compliance and adaptivity to unstructured environment. The main intricate part of such bio-inspired soft robots are soft pneumatic actuators (SPA) which replicate or mimic the limbs and muscles. The soft actuators are pneumatically actuated and provide bending motion in most cases. However, many engineering and medical applications need axially expanding soft pneumatic actuators to deal with delicate objects. Various studies have put forward designs for SPA with axial deformation, but the majority of them have limited axial deformation, constraining motion and less overall efficacy which limit the scope of utilization. The common practice to enhance the axial deformation of SPA is by incorporating directionally customized reinforcement using fibres or by other means like yarns, fabrics, etc These types of reinforcements are generally embedded to SPA during fabrication and may not have capability for any correction or modification later on hence lack the customization. This paper presents a novel method of radial reinforcement for the enhancement of axial deformation of SPAs with provision of customization. The present study aims to enhance and/or customize the axial deformation of SPA by incorporating external and detachable reinforcement in the form of annulus shaped cap ring. The investigation encompasses the design and attachment of four distinct cap ring geometries to SPA at different locations. Experimental results affirm that cap ring reinforcement bolster the radial stiffness, curbing lateral deformation while permitting axial deformation of soft pneumatic actuators. Out of 64 distinct configurations, the one with full reinforcement, featuring four cap rings of maximum size, yields a remarkable 169% increase in pure axial deformation compared to unreinforced cases. It is also observed that by varying the number and placement locations of cap rings the pure axial deformation can be customized. This novel insight not only propels soft pneumatic actuation technology but also heralds prospects for highly agile and versatile robotic systems which can be used in medical, prosthetics, pharmaceutical and other industries. 

For people who have experienced a spinal cord injury or an amputation, the recovery of sensation and motor control could be incomplete despite noteworthy advances with invasive neural interfaces. Our objective is to explore the feasibility of a novel biohybrid robotic hand model to investigate aspects of tactile sensation and sensorimotor integration with a pre-clinical research platform. Our new biohybrid model couples an artificial hand with biological neural networks (BNN) cultured in a multichannel microelectrode array (MEA). We decoded neural activity to control a finger of the artificial hand that was outfitted with a tactile sensor. The fingertip sensations were encoded into rapidly adapting (RA) or slowly adapting (SA) mechanoreceptor firing patterns that were used to electrically stimulate the BNN. We classified the coherence between afferent and efferent electrodes in the MEA with a convolutional neural network (CNN) using a transfer learning approach. The BNN exhibited the capacity for functional specialization with the RA and SA patterns, represented by significantly different robotic behavior of the biohybrid hand with respect to the tactile encoding method. Furthermore, the CNN was able to distinguish between RA and SA encoding methods with 97.84% ± 0.65% accuracy when the BNN was provided tactile feedback, averaged across three days in vitro (DIV). This novel biohybrid research platform demonstrates that BNNs are sensitive to tactile encoding methods and can integrate robotic tactile sensations with the motor control of an artificial hand. This opens the possibility of using biohybrid research platforms in the future to study aspects of neural interfaces with minimal human risk. 

Individuals who have suffered neurotrauma like a stroke or brachial plexus injury often experience reduced limb functionality. Soft robotic exoskeletons have been successful in assisting rehabilitative treatment and improving activities of daily life but restoring dexterity for tasks such as playing musical instruments has proven challenging. This research presents a soft robotic hand exoskeleton coupled with machine learning algorithms to aid in relearning how to play the piano by ‘feeling’ the difference between correct and incorrect versions of the same song. The exoskeleton features piezoresistive sensor arrays with 16 taxels integrated into each fingertip. The hand exoskeleton was created as a single unit, with polyvinyl acid (PVA) used as a stent and later dissolved to construct the internal pressure chambers for the five individually actuated digits. Ten variations of a song were produced, one that was correct and nine containing rhythmic errors. To classify these song variations, Random Forest (RF), K-Nearest Neighbor (KNN), and Artificial Neural Network (ANN) algorithms were trained with data from the 80 taxels combined from the tactile sensors in the fingertips. Feeling the differences between correct and incorrect versions of the song was done with the exoskeleton independently and while the exoskeleton was worn by a person. Results demonstrated that the ANN algorithm had the highest classification accuracy of 97.13% ± 2.00% with the human subject and 94.60% ± 1.26% without. These findings highlight the potential of the smart exoskeleton to aid disabled individuals in relearning dexterous tasks like playing musical instruments. 

Cervical disc implants are conventional surgical treatments for patients with degenerative disc disease, such as cervical myelopathy and radiculopathy. However, the surgeon still must determine the candidacy of cervical disc implants mainly from the findings of diagnostic imaging studies, which can sometimes lead to complications and implant failure. To help address these problems, a new approach was developed to enable surgeons to preview the post-operative effects of an artificial disc implant in a patient-specific fashion prior to surgery. To that end, a robotic replica of a person’s spine was 3D printed, modified to include an artificial disc implant, and outfitted with a soft magnetic sensor array. The aims of this study are threefold: first, to evaluate the potential of a soft magnetic sensor array to detect the location and amplitude of applied loads; second, to use the soft magnetic sensor array in a 3D printed human spine replica to distinguish between five different robotically actuated postures; and third, to compare the efficacy of four different machine learning algorithms to classify the loads, amplitudes, and postures obtained from the first and second aims. Benchtop experiments showed that the soft magnetic sensor array was capable of precisely detecting the location and amplitude of forces, which were successfully classified by four different machine learning algorithms that were compared for their capabilities: Support Vector Machine (SVM), K-Nearest Neighbor (KNN), Random Forest (RF), and Artificial Neural Network (ANN). In particular, the RF and ANN algorithms were able to classify locations of loads applied 3.25 mm apart with 98.39% ± 1.50% and 98.05% ± 1.56% accuracies, respectively. Furthermore, the ANN had an accuracy of 94.46% ± 2.84% to classify the location that a 10 g load was applied. The artificial disc-implanted spine replica was subjected to flexion and extension by a robotic arm. Five different postures of the spine were successfully classified with 100% ± 0.0% accuracy with the ANN using the soft magnetic sensor array. All results indicated that the magnetic sensor array has promising potential to generate data prior to invasive surgeries that could be utilized to preoperatively assess the suitability of a particular intervention for specific patients and to potentially assist the postoperative care of people with cervical disc implants. 

Multifunctional flexible tactile sensors could be useful to improve the control of prosthetic hands. To that end, highly stretchable liquid metal tactile sensors (LMS) were designed, manufactured via photolithography, and incorporated into the fingertips of a prosthetic hand. Three novel contributions were made with the LMS. First, individual fingertips were used to distinguish between different speeds of sliding contact with different surfaces. Second, differences in surface textures were reliably detected during sliding contact. Third, the capacity for hierarchical tactile sensor integration was demonstrated by using four LMS signals simultaneously to distinguish between ten complex multi-textured surfaces. Four different machine learning algorithms were compared for their successful classification capabilities: K-nearest neighbor (KNN), support vector machine (SVM), random forest (RF), and neural network (NN). The time-frequency features of the LMSs were extracted to train and test the machine learning algorithms. The NN generally performed the best at the speed and texture detection with a single finger and had a 99.2 ± 0.8% accuracy to distinguish between ten different multi-textured surfaces using four LMSs from four fingers simultaneously. The capability for hierarchical multi-finger tactile sensation integration could be useful to provide a higher level of intelligence for artificial hands.